Archive for the ‘Regenerative Medicine’ Category
Spine Surgeon Fort Worth Texas, Spine Surgeon Tarrant County, Texas Back Institute, TBI, Shawn Henry DO
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Regenerative Medicine
Administering undifferentiated stem cells to an injured disc has made adult stem cell regenerative medicine in spine a reality. Adult stem cell regenerative medicine holds the promise of stabilizing or even reversing the degenerative changes associated with aging or following traumatic injury. Current clinical use of stem cells is very limited, in part by the cumbersome approval process. The use of concentrated bone marrow aspirate (BMC) as a “stem cell” preparation is currently the simplest and safest way of utilizing the regenerative potential for mesenchymal stem cells (MSCs) to promote tissue regeneration. In fact, stem cells concentrated from bone marrow have been shown to stimulate the formation of bone, cartilage, ligament and tendon, and dermal tissues.
Conservative treatment options for lumbar and cervical pain associated with discogenic disc disease (Pfirrmann Grades 3-6) are limited. Treatment options include pain medication, steroids, physical therapy, and chiropractic care. Reversal of disc pathology has not been achieved with current available treatment modalities. Failure of these nonoperative treatments may leave surgical intervention as a treatment option.
The goal of utilizing MSCs is to not only potentially provide pain relief from the painful degenerative disc, but to reverse the degenerative process. There are three methods for placing MSCs into the painful nucleus pulposus.
The use of allogeneic mesenchymal precursor cells (MPCs) is currently being evaluated as a part of an FDA Phase I clinical trial. Extracted from donors and expanded in number by tissue culture, this process isolates and grows the stem cells into pure MPCs which are injected into the nucleus pulposus. This technology does not have FDA approval.
Utilizing expanded, autologous MSCs for injection into the painful disc is the second method. Federal regulations require the approval of an Investigational New Drug application supported by prospective, randomized clinical trials for the use of expanded autologous MSCs. The FDA has not approved this technology.
The third method involves autologous point of care therapy. This technology does not require FDA approval. The patient’s own MSCs are directly injected into the nucleus pulposus of the symptomatic degenerated disc(s) using standardized two needle discography technique. This requires fluoroscopic visualization and 2-3cc of MSCs are slowly injected into the symptomatic nucleus pulposus.
There have been no complications associated with the iliac crest aspiration or disc injection. Thus far no patient in the study has undergone spine surgery following treatment. Results obtained with this technique suggest its potential clinical efficacy in the treatment of moderate to severe degenerative disc disease. These results require verification with longer follow-up and randomized prospective studies.
For more information regarding treatment options please visit our websites at http://www.becomepainfree.com
Become Pain Free | Pain Specialist in Texas
Call Us: (214) 396-3647 | (888) 373-3720 Fax #: (888 )238-9155 | E-mail Us
Stem Cell Therapy for Spinal Disc for Spine Issues, Advances in Regenerative Medicine, PRP
With advances in Regenerative Medicine we can now offer patients the option of injecting regenerative agents such as PRP and stem cells into a damaged disc area. This includes disc annular tears, disc bulges/protrusions and disc herniations. In some cases this can help a patient avoid bigger spinal surgeries such as spinal fusion surgery. In cases where the disc herniation is very large or the disc is very damaged we offer the option of minimally invasive spinal decompression and repair and combine that procedure with either PRP or stem cells. The effect is often synergistic and in many cases very powerful. We are now at a stage where we can offer patients alternatives to spinal surgery or back surgery.
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The downside of traditional spine surgery is that you often loss range of motion after surgery or create a substantial amount of scar tissue. This does not happen when we use regenerative treatments to treat disc problems either in the lumbar or cervical region. Also with a traditional spinal fusion surgery even if the disc problem is treated successfully it often places increased stress on the disc either below or above the level of surgery or fusion. In the future this can cause that disc to degenerate and even lead to a disc herniation.
Finally, with the advancement in regenerative medicine our group can offer patients alternatives to back surgery and spinal surgery.
Call Us: (214) 396-3647 | (888) 373-3720
Fax #: (888)238-9155 | E-mail Us